Wits & Weights | Strength & Fat Loss Over 40

How He Lost 340 Pounds with Lifting, Walking (No Cardio), & GLP-1 (Jamie Selzler) | Ep 376

• Jamie Selzler • Episode 376

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0:00 | 1:07:18

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Can you really lose 340 pounds without surgery? What if the secret isn’t dieting harder, but thinking differently?

I am joined by Jamie Selzler, who completely transformed his body and life using three tools: GLP-1 medication, walking, and lifting weights, and four simple rules that kept him consistent when motivation ran out. 

Jamie reveals how he went from struggling to walk 20 feet to seeking out movement every day, why food noise nearly controlled his life, and how self-respect changed everything. Whether you want to lose 20 pounds or 200, Jamie’s story proves it can be done without extremes.

Today, you’ll learn all about:

3:06 – From avoiding movement to seeking it
6:07 – Facing mortality and fear of dying young
10:15 – Confidence versus true self-respect
14:25 – Keeping promises to yourself daily
18:03 – Food noise, GLP-1s, and relief
29:47 – Loose skin, body comp, and lifting
40:34 – Jamie’s four rules for sustainability
59:01 – Why lasting change takes years

Episode resources:


💪 Join Eat More Lift Heavy, the 26-week coached program to build muscle and lose fat after 40

📱 Get Fitness Lab, the AI coaching app for strength training and nutrition over 40

 📊 Track your nutrition with MacroFactor and use code WITSANDWEIGHTS for a 2-week free trial 

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❓ Ask a question for the show

Educational content only, not medical advice.

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